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Yanxia Hou-Broutin

Published on 1 December 2020


Researcher at CNRS since October 2008
“Correspondants Europe et international” of SyMMES
Member of Steering Committee for Labex Lanef, Co-responsible of the challenge “Nanosensors and nanomaterials for healthcare and biology” at Labef
• “Membres du bureau” and “Représentants d'Auvergne-Rhône-Alpes au conseil de direction” for GDR BIOMIM, “Conseil scientifique” and “Co-animateur scientifique” for the theme “Sentir, ressentir, percevoir” at GDR BIOMIM
Member of the Steering Committee and Member of the Organizing Committee of French-American Workshop
Co-founder and Scientific counselor of Aryballe Technologies
International Advisory Board of Analytical and Bioanalytical Chemistry


Sep 2019: HDR at “Ecole Doctorale Chimie & Sciences du Vivant”, Université Grenoble Alpes (France)
Since Oct 2008: Researcher at CNRS
Jan 2007 - Sep 2008: Postdoc, CEA-Leti/DTBS (France)
Jan 2006 - Dec 2006: Postdoc, University of California San Francisco, Touro University (USA)
Sep 2002 - Nov 2005: PhD in Analytical Chemistry, Ecole Centrale de Lyon (France)
Sep 1999 - July 2002: Master in Chemistry, Central China Normal University (China)

Research interests

• Design new biosensors/biochips based on key-and-lock principle for health-related applications

Electronic noses/tongues
• Artificial olfaction
• Design novel opto-electronic noses/tongues
• Exploration for their real-life applications in various domains (food safety, food quality control, air quality monitoring, counterfeit, health and well being, etc.)

Surface chemistry
• Thin film deposition (Self-assembled monolayers, Langmuir-Blodgett, electro- polymerisation, spin coating, etc.)
• Surface functionalization (Au, Ag, glass, SiO2, Fe2O3)
• Surface analysis and characterisation (SEM, AFM, XPS, SPR, QCM, Electrochemistry such as impedance and CV, contact angle, etc.)

• Engineer the interface between nanoparticles and biological world to render them multifunctional for nanomedicine applications


European projects:
H2020-FETOPEN (Project Abiomater 11/2015-10/2018)
EURONANMMED II (Project Nanoviber 01/2017-12/2019)

National projects:
ANR Project OBP-Optinose (coordinator, 03/2019-02/2022)
ANR project Sentinel (10/2019 - 09/2023)
ANR Project Nano-SHARK (11/2011-10/2015)
FUI Project WISE (07/2016-06/2019

Local projects:
Fondation Nanosciences (PhD program 12/2017-11/2020, Chair of Industrial Excellence Program 2017-2019)
Labex Lanef PhD program (11/2019-10/2022, 10/2012-09/2015)
Labex Arcane AAP Valo (Project Supernose, 06/2015-05/2016)
CEA DRF Impulsion (Project Hybridimer, 01/2018-02/2020)
Programme Transversal de Compétences du CEA (Projet Graphon, 10/2019 – 09/2020)
Programme Transversal Nanosciences CEA (Project NanoGAGs2Gre 10/2013-09/2015)

Industrial contracts:
Specific contracts with Aryballe Technologies (2014-2019)

Prize and Award

The EARTO (European Association of Research and Technology Organisations) Innovation Awards: 2nd prize in the category “Impact delivered” (2018).


DRF highlight, De bons yeux pour un nez opto-électronique !, June 2020

  Jonathan Weerakkody (3rd year of PhD) - Winner of Graphical abstract, (Labex Arcane, March 2020)

Scientifique, Toi Aussi, Visit of high school students, January 2020

Radio: Emission CQFD, Radio Télévision Suisse,
“Le défi du nez artificiel”, 10 June 2019

Radio : La Quadrature du Cercle N°38
“Nez Electroniques et odorat avec Yanxia Hou-Broutin”, April 2019

  MinaNews #57 December 2019
"Fromage, vin et framboise au menu des biocapteurs olfactifs"

Front cover of The Journal of Physical Chemistry, 2020

  Le Journal du Dimanche 04/07/2017

Lettre de CNRS Innovation, 20/10/2016 (Link)

CNRS International magazine 2013, N° 28, page 11

Communiqué de presse du CNRS-Paris, 18/10/2012

MinaNews of Minatec, 2012, N°22

Communiqué de presse CNRS-Alpes, 19/10/2012

Press release by Angew. Chem. Int. Ed. (Link)

Communiqué de presse CEA, 18/10/2017

Communication CEA-DSM, 24/10/2012

Newsletter of Giant, 06/11/2012

Scientific publications

[34] Aqueous Synthesis of DNA-Functionalized Near-Infrared AgInS2/ZnS Core/Shell Quantum Dots
A. Delices, D. Moodelly, C. Hurot, Y. Hou, W. L. Ling, C. Saint-Pierre, D. Gasparutto, G. Nogues, P. Reiss, K. Kheng*
ACS Appl. Mater. Interfaces, 2020, 12, 39, 44026–44038.

[33] Cancer Treatment by Magneto-Mechanical Effect of Particles, a review
C. Naud, C. Thébault, M. Carrière, Y. Hou, R. Morel, F. Berger, B. Diény, H. Joisten*
Nanoscale Advances, 2020.
[32] Bio-Inspired Strategies for Improving the Selectivity and Sensitivity of Artificial Noses: A Review
C. Hurot, N. Scaramozzino, A. Buhot, Y. Hou*
Sensors, 2020, 20, 1803.

[31] Improvement of Sensitivity of Surface Plasmon Resonance Imaging for the Gas-Phase Detection of Volatile Organic Compounds
S. Brenet, J. S. Weerakoddy, A. Buhot, F. X. Gallat, R. Mathey, L. Leroy, T. Livache, C. Herrier, Y. Hou*
Talanta, 2020, 212, 120777. (Featured article)
[30] Optical Index Prism Sensitivity of Surface Plasmon Resonance Imaging in Gas Phase: Experiment vs. Theory
J. S. Weerakkody, S. Brenet, T. Livache, C. Herrier, Y. Hou, A. Buhot*
The Journal of Physical Chemistry, 2020, 124, 6, 3756-3767. (Front cover)
[29] Development of an optoelectronic nose based on surface plasmon resonance imaging with peptide and hairpin DNA for sensing volatile organic compounds
S. Gaggiotti, C. Hurot, J. S. Weerakkody, R. Mathey, A. Buhot, M. Mascini, Y. Hou*, D. Compagnone*
Sensors and Actuators: B. Chemical, 2020, 127188.

[28] Optical Response of Magnetically Actuated Biocompatible Membranes
H. Joisten*, A. Truong, S. Ponomareva, C. Naud, R. Morel, Y. Hou, I. Joumard, S. Auffret, P. Sabon, B. Dieny
Nanoscale, 2019, 11, 10667.
[27] Highly sensitive olfactory biosensors for the detection of volatile organic compounds by surface plasmon resonance imaging
C. Hurot, S. Brenet, A. Buhot, E. Barou, C. Belloir, L. Briand, Y. Hou*
Biosensors and Bioelectronics, 2019, 123, 230-236.

[26] Highly-Selective Optoelectronic Nose Based on Surface Plasmon Resonance Imaging for Sensing Volatile Organic Compounds
S. Brenet, A. John-Herpin, F. X. Gallat, B. Musnier, A. Buhot, C. Herrier, T. Rousselle, T. Livache, Y. Hou*
Analytical Chemistry, 2018, 90 (16), 9879 -9887.

[25] Mode of PEG coverage on carbon nanotubes affects binding of innate immune protein C1q
A. Belime, E. Gravel, S. Brenet, S. Ancelet, Y. Hou, Nicole Thielens, Eric Doris, Wai Li Ling*
The Journal of Physical Chemistry B, 2018, 122, 757-763.

[24] Fabrication of monodisperse magnetic nanoparticles released in solution using a block copolymer template
M. Morcrette, G. Ortiz, S. Tallegas, H. Joisten*, R. Tiron, T. Baron, Y. Hou, S. Lequien, A. Bsiesy, B. Dieny
Journal of Physics D: Applied Physics, 2017 (50) 295001.

[23] A Versatile Electronic Tongue Based on Surface Plasmon Resonance Imaging and Cross-Reactive Sensor Arrays - A Mini-review
L. A. Garçon, M. Genua, Y. J. Hou, A. Buhot, R. Calemczuk, T. Livache, M. Billon, D. Bonnaffé, H. Lortat-Jacob, Y. Hou*
Sensors, 2017, 17, 1046.

[22] Fabrication of nanotweezers and their remote actuation by magnetic fields
C. Iss, G. Ortiz, A. Truong, Y. Hou, T. Livache, R. Calemczuk, P. Sabon, E. Gautier, S. Auffret, H. Joisten, and B. Dieny*
Scientific Reports, 2017, 7, Article number: 451.

[21] Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane
S. Leulmi, X. Chauchet, M. Morcrette, G. Ortiz, H. Joisten, P. Sabon, T. Livache, Y. Hou, M. Carrière, S. Lequiena, B. Dieny*
Nanoscale, 2015, 7, 15904–15914.

[20] Integrating Multi-Functionalities into Non-Spherical Microparticles Fabricated by Top-Down Approach
M. Genua, N. Reinhardt, J. Faure-Vincent, R. Calemczuk, T. Livache, Y. Hou*
Science of Advanced Materials, 2015, 7, 1779-1784.

[19] SPR imaging based electronic tongue via landscape images for complex mixture analysis
M. Genua, L. A. Garçon, V. Mounier, H. Wehry, A. Buhot, M. Billon, R. Calemczuk, D. Bonnaffé, Y. Hou, T. Livache
Talanta, 2014, 130, 49-54.

[18] Electronic tongue generating continuous recognition patterns for protein analysis
Y. Hou, M. Genua, L. A. Garçon, A. Buhot, R. Calemczuk, D. Bonnaffé, H. Lortat-Jacob, T. Livache
Journal of Visualized Experiments, 2014, e51901.

[17] Landscapes of taste by a novel electronic tongue for the analysis of complex mixtures
L. A. Garçon, Y. J. Hou, M. Genua, A. Buhot, R. Calemczuk, D. Bonnaffé, Y. Hou, T. Livache
Sensor Letters, 2014, 12, 1-6.

[16] Continuous evolution profiles for electronic tongue based analysis
Y. Hou, M. Genua, D. Tada Batista, R. Calemczuk, A. Buhot, P. Fornarelli, J. Koubachi, D. Bonnaffé, E. Saesen, C. Laguri, H. Lortat-Jacob, T. Livache
Angewandte Chemie International Edition, 2012,51, 10394-10398.

[15] An artificial ion channel biosensor in human immunodeficiency virus gp41 drug sensing
Y. Hou, M. Gochin
Anal. Chem., 2008, 80, 5924-5929.

[14] A novel detection strategy for odorant molecules based on a controlled bioengineering of rat olfactory receptor 17 (OR 17)
Y. Hou, N. Jaffrezic-Renault, C. Martelet, A. Zhang, J. Minic, T. Gorojankina, M. A. Persuy, E. Pajot-Augy, R. Salesse, V. Akimov, L. Reggiani, C. Pennetta, E. Alfinito, O. Ruiz, G. Gomila, J. Samitier, A. Errachid
Biosensors and Bioelectronics, 2007, 22, 1550-1555.

[13] Gold surface functionalization and patterning for specific immobilization of olfactory receptor carried by nanosomes
J. Vidic, M. Pla-Roca, J. Grosclaude, M. A. Persuy, R. Monnerie, D. Caballero, A. Errachid, Y. Hou, N. Jaffrezic-Renault, R. Salesse, E. Pajot-Augy, J. Samitier
Analytical Chemistry, 2007, 79, 3280-3290.

[12] Immobilization of Rhodopsin on a self-assembled multilayer and its specific detection by electrochemical impedance spectroscopy
Y. Hou, S. Helali, A. Zhang, N. Jaffrezic-Renault, C. Martelet, J. Minic, T. Gorojankina, M. A. Persuy, E. Pajot-Augy, R. Salesse, F. Bessueille, J. Samitier, A. Errachid, V. Akinov, L. Reggiani, C. Pennetta, E. Alfinito
Biosensors and Bioelectronics, 2006,21, 1393-1402.

[11] Detection of olfactory receptor I7 self assembled multilayer formation and immobilization using Quartz Crystal Microbalance
S. Rodríguez Seguí, M. Pla, J. Minic, E. Pajot-Augy, R. Salesse, Y. Hou, N. Jaffrezic-Renault, C. A. Mills, J. Samitier, A. Errachid
Analytical Letters, 2006, 39, 1735-1745.

[10] Advances in the production, immobilization, and electrical characterization of olfactory receptors for olfactory nanobiosensor development
G. Gomila, I. Casuso, A. Errachid, O. Ruiz, E. Pajot, J. Minic, T. Gorojankina, M. A. Persuy, J. Aioun, R. Salesse, J. Bausells, G. Villanueva, G. Rius, Y. Hou, N. Jaffrezic, C. Pennetta, E. Alfinito, V. Akimov, L. Reggiani, G. Ferrari, L. Fumagalli, M. Sampietro, J. Samitier
Sensors and Actuators B, 2006,116, 66-71.

[9] Study of Langmuir and Langmuir-Blodgett films of odorant-binding protein/amphiphile for odorant biosensor
Y. Hou, N. Jaffrezic-Renault, C. Martelet, C. Tlili, A. Zhang, J. C. Pernollet, L. Briand, G. Gomila, A. Errachid, J. Samitier, L. Salvagnac , B. Torbiéro, P. Temple-Boyer
Langmuir, 2005, 21, 4058-4065.

[8] Elaboration of odorant biosensors based on Langmuir-Blodgett technique
Y. Hou, N. Jaffrezic-Renault , C. Martelet, C. Tlili, A. Zhang
Journal of Advanced Science, 2005,17, 49-54.

[7] Immobilization of native membrane-bound rhodopsin on biosensor surfaces
J. Minic, J. Grosclaude, J. Aioun, M. A. Persuy, T. Gorojankina, R. Salesse, E. Pajot-Augy, S. Helali, Y. Hou, N. Jaffrezic-Renault, F. Bessueille, A. Errachid, G. Gomila, O. Ruiz, J. Samitier
Biochimica et Biophysica Acta (BBA), 2005, 1724, 324-332.

[6] Quantitative determination of Zinc in milkvetch by anodic stripping voltammetry with bismuth film electrodes
Z. Guo, F. Feng, Y. Hou, N. Jaffrezic-Renault
Talanta, 2005, 65, 1052-1055.

[5] Impedancemetric probing of mixed amphiphile-antibody films transferred onto silver electrodes
T. Chaker, Y. Hou, H. Korri-Youssfi, L. Ponsonnet, C. Martelet, A. Errachid, N. Jaffrezic-Renault
Sensor letters, 2005, 2,1-6.

[4] Study of mixed Langmuir-Blodgett films of immunoglobulin G/amphiphile and their application for immunosensor engineering
Y. Hou, C. Tlili, N. Jaffrezic-Renault, A. Zhang, C. Martelet, L. Ponsonnet, A. Errachid, J. Samitier, J. Bausells
Biosensors and Bioelectronics, 2004,20, 1126-1133.

[3] Study of pure urease Langmuir-Blodgett film and application for biosensor development
Y. Hou, N. Jaffrezic-Renault, A. Zhang, J. Wan, A. Errachid, J. M. Chovelon
Sensors and Actuators B, 2002, 86, 143-149.

[2] Mixed urease/amphiphile LB films and their application for biosensor development
A. Zhang, Y. Hou, N. Jaffrezic-Renault, J. Wan, A. Soldatkin, J. M. Chovelon
Bioelectrochemistry, 2002, 56, 157-158.

[1] Optimization of the mixed urease/amphiphile Langmuir-Blodgett film and its application for biosensor development
A. Zhang, N. Jaffrezic-Renault, J. Wan, Y. Hou, J. M. Chovelon
Material Science and Engineering C, 2002,21, 91-96.


[5] Système de détection pour nez électronique permettant une classification physicochimique des odeurs et nez électronique comprenant un tel système
Y. Hou-Broutin, S. Brenet, A. Buhot, C. Herrier, T. Rousselle, T. Livache, FR1907884, 2019.

[4] Composés chimiques mis en œuvre comme surfaces de référence pour déterminer le bruit d'un capteur multiplexé de type nez électronique et d'en diminuer la dérive
Y. Hou-Broutin, S. Brenet, T. Livache, C. Herrier, T. Rousselle, FR1758547, 2017.

[3] Procédé de calibration d'un nez électronique
T. Livache, F.X. Gallat, Y. Hou-Broutin, C. Herrier, T. Rousselle, FR1751751, 2017.

[2] Capteurs de nez ou de langue électronique
T. Livache, A. Buhot, D. Bonnaffé, Y. Hou-Broutin, 2013, WO2013/124810.

[1] Device for detecting gases and/or volatile organic compounds (VOC)
Delapierre Guillaume, Hou-Broutin Yanxia, Mccaig Heather, Myers Edward, Roukes Michael L., 2011, WO201136565.

Book Chapters

[3] Nanobiosensors based on individual olfactory receptors
V. Akimov, E. Alfinito, J. Bausells, I. Benilova, I. C. Paramo, A. Errachid, G. Ferrari, L. Fumagalli, G. Gomila, J. Grosclaude, Y. Hou, N. Jaffrezic-Renault, C. Martelet, E. Pajot-Augy, C. Pennetta, M. A. Persuy, M. Pla-Roca, L. Reggiani, S. Rodriguez-Segui, O. Ruiz, R. Salesse, J. Samitier, M. Sampietro, A. P. Soldatkin, J. Vidic, G. Villanueva
Analog Integrated Circuits and Signal Processing, Springer Netherlands, 2008, Vol 57, 197-203.

[2] Nanostructuration and nanoimaging of biomolecules for biosensors
C. Martelet, N. Jaffrezic-Renault, Y. Hou, A. Errachid, F. Bessueille
Applied Scanning Probe Methods VII, Springer-Verlag, Heidelberg, 2007, Vol 6, 225-257.

[1] Towards the realization of noanobiosensors based on G-protein coupled receptors
C. Pennetta, V. Akimov, E. Alfinito, L. Reggiani, T. Gorojankina, J. Minic, E. Pajot-Augy, M. A. Persuy and R. Salesse I. Casuso, A. Errachid, G. Gomila, O. Ruiz, J. Samitier, Y. Hou, N. Jaffrezic, G. Ferrari, L. Fumagalli, M. Sampietro
Nanodevices for the Life sciences, Wiley, 2006, Vol 7, 217-241.

Peer reviewed proceeding papers

[4] Odorant-binding protein-based optoelectronic tongue and nose for sensing volatile organic compounds
C. Hurot, A. Buhot, É. Barou, C. Belloir, L. Briand, Y. Hou*
2019 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 2019, page 1-4.

[3] Opto-electronic nose-Temperature and VOC concentration effects on the equilibrium response
J. S. Weerakkody, C. Hurot, S. Brenet, R. Mathey, C. Raillon, T. Livache, A. Buhot*, Y. Hou*
2019 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 2019, page 1-3.

[2] Development of a novel multiplexed optoelectronic nose for analysis of volatile organic compounds
S. Brenet, A. John-Herpin, F. X. Gallat, T. Livache, A. Buhot, C. Herrier, T. Rousselle, Y. Hou*
2017 ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 2017, page 1-3.

[1] Development of an artificial nose integrating NEMS and biological olfactory receptors
G. Gomila, A. Errachid, F. Bessueille, O. Ruiz, E. Pajot, J. Minic, T. Gorojankina, R. Salesse, G. Villanueva, J. Bausells, C. Pennetta, E. Alfinito, F. Della Sala, V. Akimov, L. Reggiani, Y. Hou, N. Jaffrezic, G. Ferrari, L. Fumigalli, M. Sampietro, J. Samitier
Conference on Electron Devices, 2005 Spanish, Tarragona, 2005, page 529-532.