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Oxidative stress

Published on 2 November 2022
Pascale Delangle & Jean-Luc Ravanat

Numerous chemical, cellular and pathological processes lead to the formation of oxidizing species in cells. Those include mostly oxygen and nitrogen reactive species (ROS and RNS). CIBEST is interested by oxidative stress in many of its research axes. Metals are very efficient at producing ROS through redox chemistry like the Fenton reaction. Cell respiration and inflammation are examples of natural production of oxidizing species, normally balanced by the presence of antioxidant chemicals and enzymes. Exposure to ionizing radiation or UVA light is also at the origin of oxidative stress.