Address IRIG/SyMMES
CEA-Grenoble, 17 avenue des Martyrs
38054 Grenoble Cedex 9
France
Scientific Interests I am interested in the interactions of metals with living systems. I aim at developing chemical tools to dissect these interactions at the molecular level, in the case of endogenous metals like Cu or Ni, or in the case of exogenous metals like lanthanides and actinides.
Research and professional experience 
Since October 2020: researcher at CEA-Grenoble, France.

2016-2020: Post-doctoral position, laboratory of Prof. Dorothea Fiedler (FMP-Berlin, Germany)
topic:
Chemical Biology tools to investigate the role of inositol pyrophosphates 
2012-2015: PhD in chemistry, supervised by Prof. Clotilde Policar and Dr. Nicolas Delsuc (ENS Paris, France)
topic:
Rhenium tricarbonyl complexes for the labelling and multimodal imaging of peptides and proteins
Education 2008-2012: Diploma of Chemistry (minor: Biology) of Ecole Normale Supérieure (Paris, France)
2011: Master’s degree in Molecular and Cell Biology (Cell Systems Biology) (Université Pierre et Marie Curie, Paris, France)
2009: Bachelor’s degree in Chemistry (Université Pierre et Marie Curie, Paris, France)
Scientific activities Member of the French Chemical Society
Member of the Society of Bio-Inorganic Chemistry
Member of Arcane Scientific Advisory Board
Member of the
FrenchBIC network
Publications 2021
Hostachy, S.; Utesch, T.; Franke, K.; Dornan, G. L.; Furkert, D.; Türkaydin, B.; Haucke, V.; Sun, H.; Fiedler, D. Dissecting the Activation of Insulin Degrading Enzyme by Inositol Pyrophosphates and Their Bisphosphonate Analogs.
Chem. Sci.
2021.
Zong, G.; Jork, N.; Hostachy, S.; Fiedler, D.; Jessen, H. J.; Shears, S. B.; Wang, H. New Structural Insights Reveal an Expanded Reaction Cycle for Inositol Pyrophosphate Hydrolysis by Human DIPP1.
FASEB J.
2021, 35 (2), e21275.
2020
Furkert, D.; Hostachy, S.; Nadler-Holly, M.; Fiedler, D. Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome.
Cell Chem. Biol.
2020,
27 (8), 1097-1108.e4
Li, X.; Gu, C.; Hostachy, S.; Sahu, S.; Wittwer, C.; Jessen, H. J.; Fiedler, D.; Wang, H.; Shears, S. B. Control of XPR1-Dependent Cellular Phosphate Efflux by InsP8 Is an Exemplar for Functionally-Exclusive Inositol Pyrophosphate Signaling.
Proc. Natl. Acad. Sci. U. S. A.
2020,
117 (7), 3568–3574
Sahu, S.; Wang, Z.; Jiao, X.; Gu, C.; Jork, N.; Wittwer, C.; Li, X.; Hostachy, S.; Fiedler, D.; Wang, H.; Jessen, H. J.; Kiledjian, M.; Shears, S. B. InsP7 Is a Small-Molecule Regulator of NUDT3-Mediated mRNA Decapping and Processing-Body Dynamics.
Proc. Natl. Acad. Sci. U. S. A.
2020,
117 (32), 19245–19253
2018
Hostachy, S.; Masuda, M.; Miki, T.; Hamachi, I.; Sagan, S.; Lequin, O.; Medjoubi, K.; Somogyi, A.; Delsuc, N.; Policar, C. Graftable SCoMPIs Enable the Labeling and X-Ray Fluorescence Imaging of Proteins.
Chem. Sci.
2018, 9 (19), 4483–4487
Henry, L.; Delsuc, N.; Laugel, C.; Lambert, F.; Sandt, C.; Hostachy, S.; Bernard, A. S.; Bertrand, H. C.; Grimaud, L.; Baillet-Guffroy, A.;
et al. Labeling of Hyaluronic Acids with a Rhenium-Tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging.
Bioconjug. Chem.
2018,
29 (4), 987–991
Zhang, T.; Solé-Daura, A.; Hostachy, S.; Blanchard, S.; Paris, C.; Li, Y.; Carbó, J. J.; Poblet, J. M.; Proust, A.; Guillemot, G. Modeling the Oxygen Vacancy at a Molecular Vanadium(III) Silica-Supported Catalyst.
J. Am. Chem. Soc.
2018,
140 (44), 14903–14914
2017
Hostachy, S.; Policar, C.; Delsuc, N. Re(I) Carbonyl Complexes: Multimodal Platforms for Inorganic Chemical Biology.
Coord. Chem. Rev.
2017,
351 (Supplement C), 172–188
2016
Hostachy, S.; Swiecicki, J. M.; Sandt, C.; Delsuc, N.; Policar, C. Photophysical Properties of Single Core Multimodal Probe for Imaging (SCoMPI) in a Membrane Model and in Cells.
Dalt. Trans.
2016,
45 (7), 2791–2795
Fernández, E.; Hostachy, S.; Sandt, C.; Rodríguez, G.; Bertrand, H. C.; Clède, S.; Cócera, M.; Maza, A. D. La; Lambert, F.; Policar, C.;
et al. Monitoring Bicosomes Containing Antioxidants in Normal and Irradiated Skin.
RSC Adv.
2016,
6 (76), 72559–72567
2015
Fernández, E.; Rodríguez, G.; Hostachy, S.; Clède, S.; Cócera, M.; Sandt, C.; Lambert, F.; de la Maza, A.; Policar, C.; López, O. A Rhenium Tris-Carbonyl Derivative as a Model Molecule for Incorporation into Phospholipid Assemblies for Skin Applications.
Colloids Surfaces B Biointerfaces
2015,
131, 102–107
2013
Hoffmann, C.; Mazari, E.; Gosse, C.; Bonnemay, L.; Hostachy, S.; Gautier, J.; Gueroui, Z. Magnetic Control of Protein Spatial Patterning to Direct Microtubule Self-Assembly.
ACS Nano
2013,
7 (11), 9647–9654
Bonnemay, L.; Hostachy, S.; Hoffmann, C.; Gautier, J.; Gueroui, Z. Engineering Spatial Gradients of Signaling Proteins Using Magnetic Nanoparticles.
Nano Lett.
2013,
13 (11), 5147–5152
2011
Corden, V. A.; Duhme-Klair, A. K.; Hostachy, S.; Perutz, R. N.; Reddig, N.; Becker, H. C.; Hammarström, L. Spectroscopic and Structural Investigations Reveal the Signaling Mechanism of a Luminescent Molybdate Sensor.
Inorg. Chem.
2011,
50 (3), 1105–1115
Jeffroy, M.; Weber, G.; Hostachy, S.; Bellat, J. P.; Fuchs, A. H.; Boutin, A. Structural Changes in Nanoporous MFI Zeolites Induced by Tetrachloroethene Adsorption: A Joint Experimental and Simulation Study.
J. Phys. Chem. C
2011,
115 (10), 3854–3865