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Publié le 1 septembre 2022
CEA-Grenoble, 17 avenue des Martyrs
38054 Grenoble Cedex 9

Scientific Interests
I am interested in the interactions of metals with living systems. I aim at developing chemical tools to dissect these interactions at the molecular level, in the case of endogenous metals like Cu or Ni, or in the case of exogenous metals like lanthanides and actinides.

Research and professional experience
    Since October 2020: researcher at CEA-Grenoble, France.
    2016-2020: Post-doctoral position, laboratory of Prof. Dorothea Fiedler (FMP-Berlin, Germany)
topic: Chemical Biology tools to investigate the role of inositol pyrophosphates
    2012-2015: PhD in chemistry, supervised by Prof. Clotilde Policar and Dr. Nicolas Delsuc (ENS Paris, France)
topic: Rhenium tricarbonyl complexes for the labelling and multimodal imaging of peptides and proteins

2008-2012: Diploma of Chemistry (minor: Biology) of Ecole Normale Supérieure (Paris, France)
2011: Master’s degree in Molecular and Cell Biology (Cell Systems Biology) (Université Pierre et Marie Curie, Paris, France)
2009: Bachelor’s degree in Chemistry (Université Pierre et Marie Curie, Paris, France)

Scientific activities
Member of the French Chemical Society
Member of the Society of Bio-Inorganic Chemistry
Member of Arcane Scientific Advisory Board
Member of the FrenchBIC network

Hostachy, S.; Utesch, T.; Franke, K.; Dornan, G. L.; Furkert, D.; Türkaydin, B.; Haucke, V.; Sun, H.; Fiedler, D. Dissecting the Activation of Insulin Degrading Enzyme by Inositol Pyrophosphates and Their Bisphosphonate Analogs. Chem. Sci. 2021.

Zong, G.; Jork, N.; Hostachy, S.; Fiedler, D.; Jessen, H. J.; Shears, S. B.; Wang, H. New Structural Insights Reveal an Expanded Reaction Cycle for Inositol Pyrophosphate Hydrolysis by Human DIPP1. FASEB J. 2021, 35 (2), e21275.

Furkert, D.; Hostachy, S.; Nadler-Holly, M.; Fiedler, D. Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome. Cell Chem. Biol. 2020, 27 (8), 1097-1108.e4

Li, X.; Gu, C.; Hostachy, S.; Sahu, S.; Wittwer, C.; Jessen, H. J.; Fiedler, D.; Wang, H.; Shears, S. B. Control of XPR1-Dependent Cellular Phosphate Efflux by InsP8 Is an Exemplar for Functionally-Exclusive Inositol Pyrophosphate Signaling. Proc. Natl. Acad. Sci. U. S. A. 2020, 117 (7), 3568–3574

Sahu, S.; Wang, Z.; Jiao, X.; Gu, C.; Jork, N.; Wittwer, C.; Li, X.; Hostachy, S.; Fiedler, D.; Wang, H.; Jessen, H. J.; Kiledjian, M.; Shears, S. B. InsP7 Is a Small-Molecule Regulator of NUDT3-Mediated mRNA Decapping and Processing-Body Dynamics. Proc. Natl. Acad. Sci. U. S. A. 2020, 117 (32), 19245–19253

Hostachy, S.; Masuda, M.; Miki, T.; Hamachi, I.; Sagan, S.; Lequin, O.; Medjoubi, K.; Somogyi, A.; Delsuc, N.; Policar, C. Graftable SCoMPIs Enable the Labeling and X-Ray Fluorescence Imaging of Proteins. Chem. Sci. 2018, 9 (19), 4483–4487

Henry, L.; Delsuc, N.; Laugel, C.; Lambert, F.; Sandt, C.; Hostachy, S.; Bernard, A. S.; Bertrand, H. C.; Grimaud, L.; Baillet-Guffroy, A.; et al. Labeling of Hyaluronic Acids with a Rhenium-Tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging. Bioconjug. Chem. 2018, 29 (4), 987–991

Zhang, T.; Solé-Daura, A.; Hostachy, S.; Blanchard, S.; Paris, C.; Li, Y.; Carbó, J. J.; Poblet, J. M.; Proust, A.; Guillemot, G. Modeling the Oxygen Vacancy at a Molecular Vanadium(III) Silica-Supported Catalyst. J. Am. Chem. Soc. 2018, 140 (44), 14903–14914

Hostachy, S.; Policar, C.; Delsuc, N. Re(I) Carbonyl Complexes: Multimodal Platforms for Inorganic Chemical Biology. Coord. Chem. Rev. 2017, 351 (Supplement C), 172–188

Hostachy, S.; Swiecicki, J. M.; Sandt, C.; Delsuc, N.; Policar, C. Photophysical Properties of Single Core Multimodal Probe for Imaging (SCoMPI) in a Membrane Model and in Cells. Dalt. Trans. 2016, 45 (7), 2791–2795

Fernández, E.; Hostachy, S.; Sandt, C.; Rodríguez, G.; Bertrand, H. C.; Clède, S.; Cócera, M.; Maza, A. D. La; Lambert, F.; Policar, C.; et al. Monitoring Bicosomes Containing Antioxidants in Normal and Irradiated Skin. RSC Adv. 2016, 6 (76), 72559–72567

Fernández, E.; Rodríguez, G.; Hostachy, S.; Clède, S.; Cócera, M.; Sandt, C.; Lambert, F.; de la Maza, A.; Policar, C.; López, O. A Rhenium Tris-Carbonyl Derivative as a Model Molecule for Incorporation into Phospholipid Assemblies for Skin Applications. Colloids Surfaces B Biointerfaces 2015, 131, 102–107

Hoffmann, C.; Mazari, E.; Gosse, C.; Bonnemay, L.; Hostachy, S.; Gautier, J.; Gueroui, Z. Magnetic Control of Protein Spatial Patterning to Direct Microtubule Self-Assembly. ACS Nano 2013, 7 (11), 9647–9654

Bonnemay, L.; Hostachy, S.; Hoffmann, C.; Gautier, J.; Gueroui, Z. Engineering Spatial Gradients of Signaling Proteins Using Magnetic Nanoparticles. Nano Lett. 2013, 13 (11), 5147–5152

Corden, V. A.; Duhme-Klair, A. K.; Hostachy, S.; Perutz, R. N.; Reddig, N.; Becker, H. C.; Hammarström, L. Spectroscopic and Structural Investigations Reveal the Signaling Mechanism of a Luminescent Molybdate Sensor. Inorg. Chem. 2011, 50 (3), 1105–1115

Jeffroy, M.; Weber, G.; Hostachy, S.; Bellat, J. P.; Fuchs, A. H.; Boutin, A. Structural Changes in Nanoporous MFI Zeolites Induced by Tetrachloroethene Adsorption: A Joint Experimental and Simulation Study. J. Phys. Chem. C 2011, 115 (10), 3854–3865