Thesis presented October 24, 2013

Abstract:
The objective of this thesis is to develop an electronic language with a simplified method of obtaining cross-reactive receivers. These receptors are prepared by an innovative combinatorial approach consisting of mixing and self-assembly of two disaccharides. Coupling these receptors with a surface plasmon resonance imaging detection system enabled us to achieve an electronic tongue capable of differentiating samples of different complexities, including pure proteins and complex mixtures. This is done through profiles and images of continuous evolution, assimilated to "fingerprints" samples. On the other hand, this system can be used as a tool for the design of 2D and 3D biomimetic surfaces. This system is promising for the study of sugar-protein interactions and for the preparation of biomimetic nanovectors that specifically target proteins of interest.

Keywords:
Electronic tongue, Combinatorial cross-reactive receptor array, SPR imaging, Pattern recognition, Heparan sulfate, Biomimetic nanovectors

On-line thesis.