SummaryThis internship objective is to
develop original nano-architected materials to improve the sensitivity and selectivity of optoelectronic noses. The latter are developed and studied in the SyMMES laboratory (UMR 5819 CEA-UGA-CNRS) in the context of volatile organic compounds (VOCs) analysis, with potential applications in environmental monitoring (air quality control...), security (explosive detection...). To do so, we wish to
explore and characterize new materials based on DNA self-assembly selectively hybridized to carry the sensitive part constituted by a "trap cavity" (porphyrins (Porph.), calixarenes (Calix.) or cyclodextrins (Cyc.). Thus, the new bio-hybrid nano-architecture DNA-Cyc, DNA-Porph or DNA-Calix will be used as original building blocks, possessing within them both the sensing function (hydrophobic cavities of Cyc., Porph., Calix. for the recognition-complexation of VOCs) and the structuring function (DNA strands for the recognition assembly by selective hybridization). These new sensing materials will then be integrated onto the SPRi chip for the development of electronic nose for the analysis of VOCs with high-societal impact.
Related references J. S. Weerakkody, M. El Kazzy, E. Jacquier, P. H. Elchinger, R. Mathey, W. L. Ling, C. Herrier, T. Livache, A. Buhot, Yanxia Hou, Surfactant-like Peptide Self-assembled into a Biohybrid Multi-sensor Array for an Electronic Nose,
ACS Nano, 2022, 16, 3, 4444.
E. Jacquier, P.-H. Jouneau, D. Falconet, D. Mariolle, E. Thévenon, G. Si Larbi, R. Tiron, F. Parcy, P.-H. Elchinger, and R. Dumas: Self-Assembly of a Ginkgo Oligomerization Domain Creates a Sub-10-nm Honeycomb Architecture on Carbon and Silicon Surfaces with Customizable Pores: Implications for Nanoelectronics, Biosensing, and Biocatalysis.
ACS Applied Nano Materials 09/2021.
C. Brun, P.-H. Elchinger, G. Nonglaton, C. Tidiane-Diagne, R. Tiron, A. Thuaire, D. Gasparutto, X. Baillin: Metallic Conductive Nanowires Elaborated by PVD Metal Deposition on Suspended DNA Bundles.
Small 07/2017.
C.Brun, C. Tidiane-Diagne, P.-H. Elchinger, S. Torrengo, A. Thuaire, D. Gasparutto, R. Tiron, X. Baillin: Deoxyribonucleic Acid for Nanopackaging.
IEE Nanotechnology magazine, 03/2017.
Background and skills expected
The appetence for multidisciplinary practice is required.
Multidisciplinary internship (depending on profile formation will be provided to perform the internship efficiently)
Competences that will be acquired during the internship Physics: AFM & SEM characterization, SPRi Analysis
Chemistry: Click-chemistry reaction (link DNA-trap cavity), DNA manipulation (labelling, self-assembling)
Sensor: electronic nose, analysis of VOCs by SPRi.
SupervisorDr. Pierre-Henri Elchinger
LaboratorySystèmes Moléculaires et nanoMatériaux pour l'Énergie et la Santé (SyMMES UMR 5819 CEA-CNRS-UGA)
Chimie pour la Reconnaissance et l’Etude d’Assemblages Biologiques (CREAB)
Contact-eMailPierre-Henri ElchingerIRIG, CEA-Grenoble,
17 avenue des Martyrs, 38054 Grenoble cedex 9, France
Tel: 04 38 78 64 96