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To mimic the copper transport protein Ctr1, responsible for copper entrance into cells, several molecular architectures based on the symmetric scaffold, nitrilotriacetic acid (NTA) functionalized with three amino acids bearing thioether side chains were designed. These thioether derivatives form mononuclear complexes of Cu(I) with significantly higher affinity compared to Ctr1 models and are of great interest for applications in copper chelation therapy.
Thesis presented November 15, 2019 by Laura Gauthier.
Thesis presented December 12, 2018 by Edit Mesterhazy. PhD thesis available as a pdf file.
Thesis presented November 27, 2017 by Elena Salvadeo. PhD thesis available in Intranet as a pdf file.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.